Thus, it can be conceivable the JIP1/three???ASK1???MKK4 signaling module may well function a conduit to activate JNK when endosomal trafficking is disrupted and glucose levels fall during the early stages of methuosis. Our acquiring that MKK4 was robustly activated by the methuosis-inducing IPPs, MOMIPP and 2q, and fewer so with the non-cytotoxic